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Friday, May 15, 2020 | History

3 edition of Molecular mimicry found in the catalog.

Molecular mimicry

Molecular mimicry

cross-reactivity between microbes and host proteins as a cause of autoimmunity

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Published by Springer-Verlag in Berlin, London .
Written in English


Edition Notes

Statementedited by M.B.A. Oldstone.
SeriesCurrent topics in microbiology and immunology -- 145
ContributionsOldstone, Michael B. A.
ID Numbers
Open LibraryOL21343047M
ISBN 100387509291

  Molecular mimicry. Scientists view autoimmunity as the prolonged and pathological response that arises when the immune system gets confused between “self” and “non-self” due to molecular similarities between an environmental agent and the host. The specific hypothesis—called molecular mimicry—is that “either a virus or bacteria initiate and exacerbate an autoimmune . Molecular mimicry occurs at different levels, including complete identity or homology at the protein level, similarity at the amino acid sequences, and structural similarity [21]. Also, molecular.

Molecular mimicry is when one molecule mimics another one in the way it behaves in the body. Specifically, it’s when the immune system mistakes one antigen (or potential pathogen) for another. But before I explain how this can lead to autoimmunity, allow me to recap how the immune system works. ISBN: OCLC Number: Description: xvii, pages: illustrations (some color) ; 26 cm: Contents: Foreword / Michael B.A. Oldstone --An Overview: Molecular Mimicry and Disease / Kumar Visvanathan, John B. Zabriskie --Principles of Molecular Mimicry and Autoimmune Disease / Irun R. Cohen --Molecular Mimicry and Central Nervous System Autoimmune Disease / .

Molecular Mimicry, A Case of Mistaken Identity Every time your body is exposed to a bacteria, virus, or other pathogen, your immune system memorizes its structure, specifically its protein sequence, so that it can recognize it in the future and mount a defense. The mystery of molecular mimicry () Dr. Tom’s new book and a gift for listeners () I know you’ll love all the educational information from this episode of The Broken Brain Podcast as much as I did. Wishing you health and happiness, Mark Hyman, MD.


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Molecular mimicry Download PDF EPUB FB2

Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology ()) th Edition by Michael B. Oldstone (Editor) ISBN ISBN Why is ISBN important.

ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book. Price: Molecular mimicry book Buy Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology Book ): Read Kindle Store Reviews - Molecular Mimicry: Infection Inducing Autoimmune Disease (Current Topics in Microbiology and Immunology Book ) - Kindle edition by Oldstone, Michael B.

cturer: Springer. This volume focuses on the evidence for or against molecular mimicry as a cause of autoimmunity. Contributions from recognized experts present their original findings, and the final chapter reviews the overall perspective of molecular mimicry.

This new book is the first comprehensive review of molecular mimicry. It offers an examination of the origins of the field, the current status, and the new developments that could lead to a better understanding of molecular mimicry and how infectious agents trick the host immune system to turn against a particular organ or group of organs in Molecular mimicry book human body.

One of the most intensively studied animal models of autoimmunity is insulin-dependent diabetes mellitus (IDDM) in the nonobese diabetic (NOD) mouse.

This chapter considers how molecular mimicry, when viewed in the broader context of degeneracy of T-cell recognition specificity, provides a rationale for the existence of frequent : Anthony Quinn, Eli E. Sercarz. One of the mechanisms involved in induction of an autoimmune response is molecular mimicry.

The healthy immune system is tolerant to the molecules which are the building bricks of our body. Braking the self tolerance due to clonal escape, DNA rearrangement epigenetic and environmental factors, all in concert with genetic predisposition, may lead to an autoimmunity termed “The mosaic of Author: Miri Blank, Eitan Israeli, Smadar Gertel, Howard Amital, Yehuda Shoenfeld.

Purchase Antibodies, Antigens, and Molecular Mimicry, Volume - 1st Edition. Print Book & E-Book. ISBNMolecular mimicry is the occurrence of common B or T cell reactive epitopes between microorganisms or environmental agents and the host, and the pathogenic consequence of such cross-reactivity.

Molecular mimicry has been demonstrated to occur in several different forms including complete identity at the protein level, homology at the protein level, similarity at the level of amino acid sequences and.

Question 2 Molecular mimicry with human myocardial myosin is responsible for myocarditis following infection with. MOLECULAR MIMICRY Molecular mimicry is the occurrence of common B or T cell reactive epitopes between microorganisms or environmental agents and the host, and the pathogenic consequence of such cross reactivity.

It is a mechanism by which immunological self tolerance can be broken, leading to autoimmune disease. Molecular and Cellular Mechanisms, Pathogenesis, and Treatment of Insulin-Dependent Diabetes Obtained Through Study of a Transgenic Model of Molecular Mimicry Pages Oldstone, M.

The term Molecular mimicry describes the sequence similarity between foreign (microorganism's peptides) and self peptides (the host's antigen). This phenomenon has been recently discovered as a one of the major mechanism in which there is a break-down.

molecular mimicry characteristic complex of 1. Fever 2. Arthritis 3. Carditis 4. More rarely, chorea, rash, and nodules.

Post-streptococcal glomerulonephritis. Can follow streptococcal pharyngitis ( weeks) Or skin and soft tissue infections ( weeks) classical clinical syndrome 1. Currently, molecular mimicry is the prevailing hypothesis as to how viral antigens initiate and maintain autoimmune responses which lead to specific tissue damage [ 18 ].

Initial work by Fujinami, Oldstone, and colleagues identified mouse antibodies to measles virus and herpes simplex virus (HSV-1) Cited by: Buy Molecular Mimicry, Microbes and Autoimmunity: NHBS - Edited By: M Cunningham, American Society for Microbiology Press About Help Blog Jobs Established NHBS GmbH Covid £ GBP.

This volume focuses on the evidence for or against molecular mimicry as a cause of autoimmunity. Contributions from recognized experts present their original findings, and the final chapter reviews the overall perspective of molecular mimicry, how to use its principles in clinical investigation and list the conceptual traits by which autoimmune disaese can occur.

The book tells the story of viral hemorrhagic fevers like Ebola, including their origins and past outbreaks. Other work is targeted at understanding how the Kaposi’s sarcoma herpesvirus uses what Glaunsinger calls “molecular mimicry” to slip past host cells’ built-in defense systems.

Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders.

Molecular Mimicry of Human Cytochrome P by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition. molecular mimicry. Antigenic similarity between molecules found on some disease-causing microorganisms and on specific previously healthy body cells or tissues.

Molecular mimicry is one explanation for autoimmune diseases. This naturally occurring process is reflected in the concept of molecular mimicry, which has become a useful approach in drug discovery. The search for carbohydrate analogues that exhibit better binding activity, biological activity, and stability began with the synthesis of azasugars.Molecular mimicry usually has its roots in your gut, which is the home to 70% of your immune system and has a huge impact on autoimmune disease.The conceptual basis for molecular mimicry was first defined in the early s when monoclonal antibodies against viruses were also shown to react with non-viral host protein; in this case, measles virus phosphoprotein cross-reacted with host cell cytokeratin, herpes simplex virus type 1 with host-cell vimentin and vaccinia virus with host-cell intermediate filaments.